鱼类DNA甲基化研究进展

Research progress of DNA methylation in fish

中文关键词: DNA甲基化  鱼类  生物学功能  环境因子

英文关键词: DNA methylation  Fish  Biological function  Environmental factor

中文摘要:

      DNA甲基化作为DNA化学修饰的一种形式,能够在不改变DNA序列的前提下改变生物的遗传表现,对于理解基因调控机制和生物学过程具有重要作用。近年来, DNA甲基化的研究已成为热点并取得了长足进展,但其在鱼类生长发育及环境响应过程中的功能及调控机制尚不够清晰。本文对鱼类DNA甲基化的模式、生物学功能以及环境因子对DNA甲基化的影响等方面进行综述,并对未来的研究方向作出展望,以期为鱼类DNA甲基化的深入研究与应用提供参考。

英文摘要:

      DNA methylation is an important epigenetic regulatory mechanism in organisms that regulates the stability of the genome by the structure of chromosomes and proteins without altering the gene sequence.It has been widely studied and applied in the fields of medicine, agriculture, forestry and animal husbandry.In recent years, with the deepening of research on different fields of aquaculture animals, DNA methylation has attracted great attention in the field of fish genetics and fish breeding.