坛紫菜酶解产物对糖尿病模型小鼠的血糖调节作用

Hypoglycemic effect of hydrolysate of Porphyra haitanensis on diabetic model mice

中文关键词: 坛紫菜  酶解产物  糖尿病  血糖调节作用

英文关键词: Porphyra haitanensis  Enzymatic hydrolysate  Diabetes  Hypoglycemic effect

中文摘要:

      本研究通过四氧嘧啶诱导建立糖尿病小鼠模型，比较分析HPH对高血糖小鼠的体重、脏器系数、血糖值、负荷糖耐量、血清胰岛素（INS）、糖化血清蛋白（GSP）和肝糖原等指标的影响情况。结果显示，一定剂量的HPH可提高高血糖小鼠的体重增长幅度、脾脏系数、INS和肝糖原浓度，降低肝脏系数和GSP含量，但对胸腺系数的影响不大。其中，HPH中剂量组和高剂量组在给药过程中，血糖值保持稳定，显著低于高血糖模型组，且可改善糖耐量。研究表明，HPH对四氧嘧啶诱导糖尿病小鼠具有血糖调节能力。

英文摘要:

      To study the hypoglycemic effect of hydrolysate of Porphyra haitanensis on diabetes, the hyperglycemia mice were induced by alloxan to analyze the effects of HPH on weight, organ coefficient, glucose tolerance, serum insulin (INS), glycosylated serum protein (GSP), liver glycogen and so on. The result showed that the growth of weight, spleen coefficient, INS and concentration of liver glycogen in the mice were raised at certain doses of HPH, while liver coefficient and GSP were lower, but thymus coefficient remained steady. Among them, the blood glucose level of the mice treated with high and medium dose HPH were stable and were significantly lower than the control. In conclusion, HPH has obvious hypoglycemic effect on hyperglycemia mice induced by alloxan.