Abstract:Globally, infectious hypodermal and haematopoietic necrosis virus (IHHNV) is one of the major viral pathogens of penaeid shrimp, causing huge economic loss to the shrimp farming industry. Further, IHHNV has been listed as a reportable crustacean disease pathogen by the World Organization for Animal Health (OIE). It is widely distributed in China and has become an important virus affecting shrimp culture. In the present paper, IHHNV pathogenicity-related progress geographically, host range, pathogenicity type, pathogenicity in host at different growth stages, interference with white spot syndrome virus (WSSV), and pathogensis mechanism of IHHNV were reviewed. The paper aimed to provide systematic references for the studies on control of IHHNV.