Pharmacokinetics of sulfadimoxine in Olive flouder Paralichthys olivaceaus

Abstract:

The pharmacokinetics of sulfadimoxine (SDM’) in plasma, muscle and liver tissues of Paralichthys olivaceaus were analyzed using UPLC method after oral administration of 200 mg/kg SDM’ as a single dose. The results showed that the SDM’ concentrations in plasma, muscle and liver of P. olivaceaus were best described as a two-compartment model by DAS. 2.0. The time to reach maximum concentration in plasma, muscle and liver was 24 h, 24 h and 8 h, and the Cmax was 158.09 mg/kg, 43.04 mg/kg and 6.71 mg/kg, respectively. The elimination half life turned out to be 48.9 h, 501.5 h and 116.1 h. The residual time of SDM’ in P. olivaceaus was very long.