Abstract:The effects of partial replacement of fish meal (FM) with meal made from Antarctic krill Euphausia superba as protein source in the diets for turbot Scophthalmus maximus on growth, non-specific immunity and fluoride retention were studied. Four experimental diets were prepared using an FM diet as the control. The other diets included Antarctic krill where 20%, 40% or 60% of the dietary FM protein was replaced by the protein from Antarctic krill. All diets were iso-nitrogenous and iso-caloric. Four diets were fed to groups of turbot(37.36±2.12 g) for 8 weeks. Experimental results showed that in fish fed diets containing Antarctic krill, survival, specific growth rate (SGR), alkaline phosphatase(AKP), acid phosphatase (ACP), lysozyme (LZM) and total superoxide dismutase(T-SOD)were significantly different compared with fish fed the control diet(P>0.05). The apparent digestibility of each experimental group has significant difference (P<0.05), and the protein digestibility rate of 3(40) group and 4(60) group had significant difference with the control group (P<0.05). The fluoride retention in muscles of each experimental group has no significant difference (P>0.05), but in bones, each experimental group has significant difference (P<0.05).