Abstract:To investigate the food safety risk, toxic and harmful substances in shellfish of Jiaozhou Bay,Qingdao,was determined and analyzed for three years. Nearly 300 shellfish samples in 34 culture zones in Jiaozhou Bay were collected,and the total number of bacterial colony, Escherichia coli, paralytic shellfish poisoning (PSP), diarrheic shellfish poisoning (DSP), lead, copper, and cadmium were determined. The total number of bacterial colony, PSP, DSP, lead and cadmium were not detected, indicating that these shellfish met the safe standard for edible seafood. However, the microbial indicator such as E. coli exceeded the standard.According to the monitoring and the assessment results following the cultured shellfish quality index method (Sj), the shellfish in Jiaozhou Bay meets the national food safety standard. However, more attention should be paid to the pollutants in seawater of Jiaozhou Bay,in order to ensure the sea food safety.