Abstract:The effect of fish protein hydrolysate(FPH) was examined as an immuno enhancer on the non specific immune response of Penaeus chinensis. P.chinensis were fed with 0%, 5%, 10%, and 15% FPH replacing fish meal protein for 30 days. Samples were collected at the end of the experiment.The results showed that the acid phosphatase activity in the hepatopancreas of P.chinensis fed diet with 5% FPH replacing fish meal protein was significantly higher than that of other groups (P<0.05),and total haemocyte count of this treatment was significantly higher (P<0.05) than those of other treatments.The activities of acid phosphatase,alkaline phosphatase and lysozyme in the serum of P.chinensis fed with 5% FPH replacing fish meal protein were significantly higher (P<0.05) than those of other groups. Moreover,the group of 5% FPH replacing fish meal protein resulted in a significant SGR increase(P<0.05). In conclusion, fish protein hydrolysate could significantly improve the non-specific immune response of P.chinensis.