Abstract:The present study investigated pharmacokinetics and residues of nitrite in Carassius auratus. Simultaneously, the impact of chlorine and bromine ion absorption was studied. C. auratus exposed to nitrite at a concentration of 60 mg/L bath water for 10d at 18±2℃. The concentration of the drug in the serum and muscle could be described as a two compartmental open model, the main pharmacokinetics parameters are t1 /2α, t1 /2β; AUC, Cl ( s): 0.92 d, 1.50 d; 5.36 d, 7.98 d; 0.72 d*mg/L(kg), 1.10 d*mg/L(kg); 83.1 mg/L(kg)/d, 54.7 mg/L(kg)/d. The limit of quantification（LQ）was 0.01 mg/kg. The linear plots were obtained, r=0.9999. Average recoveries were between 78.0%～93.7% with RSD values between 4.88%～9.17.%. According to the maximum residue limit (MRL) of 0.02 mg/kg in muscle, the withdrawal period should not be less than 10 d under this experiment condition in C. auratus at the water temperature of 18 ±2℃. The other results showed the groups appended NaCl, NaBr were lower than only nitrite solution in three tissues. The groups appended NaCl was lowest. The results showed that effect of Cl- was better compared with Br-, and chlorine and bromine ion could reduce nitrite toxicity.
