Abstract:Residues and withdrawal periods of oxytetracycline (OTC) was evaluated by HPLC in globefish Fugu rubripes following multi-oral administration of 100 mg/kg weight body per day for 5 days at 14±2℃. The result showed that the highest concentrations of OTC in blood and muscle were found in 2 days after the last administration, which were 1.092μg/ml and 0.806μg/g, respectively. While the highest level found in liver was 1.229μg/g, 3 days post-administration. It was revealed that the elimination half lives of OTC in blood, muscle and liver were 23.8, 22.4 and 26.8 days respectively, indicating that the elimination rate of OTC in globefish was very low. OTC concentrations in the muscle of globefish fell below the 0.1μg/g and 0.05μg/g residue limits at day 58 and day 81 post-administration, respectively.
