Abstract:The pharmacokinetics, tissue metabolism and elimination of sulfamethoxazole (SMZ) was investigated in turbot Scophthalmus maximus following a single oral dose of 100mg/kg at (11±1)℃. Plasma and tissue concentration of SMZ was determined by HPLC. The concentration-time curves of SMZ in the muscle, liver and plasma fitted well to a one-compartment open model with first-order absorption. After the oral administration, the time to reach maximum SMZ concentration in the muscle, liver and plasma was 11.89 h, 10.53 h and 4.87 h, and the maximum concentration of SMZ was 21.52 mg/kg, 5.35 mg/kg and 44.07 mg/kg, respectively. 5 d, 6 d and 72 h after the administration, the SMZ content in the muscle, liver and plasma were less than the MRL (0.1 mg/kg); and it was undetectable at 18d, 24d and 10d in these tissues, respectively.
